I'm reading this node book and I'm really impressed by the simplicity and elegance in writing node and express apps. Of course, the book has trivial examples, but I can imagine being able to keep it simple even with a "real" app.
Aside from having to write Javascript instead of Python, I think I will enjoy writing node apps.
I should really play with Flask though... it might just be that this is the first I've really dived into a micro-framework.