Nothing changed until February 2007 when I added two new interests: Economics and Computational Neuroscience.
Updating the list to include those seems to have been triggered by a PyCon session I chaired.
I'd been interested in the brain and artificial intelligence since my teens (although clearly not enough to have mentioned them on my lists of interests until this point) but I think what got me back into it in 2005 was Jeff Hawkins's book On Intelligence.
I'd been blogging about economic topics since 2005 too, it just took me until early 2007 (triggered by the PyCon session) to mention it explicitly in my list of interests.